The Israeli army says 200 jets struck more than 100 sites across Iran in a large-scale attack. Israel’s military says it launched a wave of strikes on Iran, hitting key nuclear facilities and killing senior Iranian commanders and nuclear scientists in a major attack.

WASHINGTON (AP) — President Donald Trump says an Israeli attack on Iran over Tehran’s nuclear program is not imminent but “could very well happen.” “I don’t want to say imminent, but it looks like it’s something that could very well happen,” Trump told reporters at the White House on Thursday.

Russian President Vladimir Putin held phone calls with Israeli Prime Minister Benjamin Netanyahu and Iranian President Masoud Pezeshkian on Friday after Israel pelted Iran with a series of strikes.

"We have taken note with great concern of the various statements concerning a considerable increase in enrichment capacity, and in particular, the establishment of new infrastructure."

World powers respond to rising Middle East tensions as Israel strikes Iranian sites. The U.S. insists it was not involved in strikes, and the much of the globe urges restraint.

The reaction was noticeably different on Friday than it was after the last time Israel attacked Iran, when several countries provided backup and resources.

While this is not the first confrontation between the two arch-foes, the direct targeting of nuclear sites has sent shockwaves across the globe.