Notre Dame and Penn State are set for the College Football Playoff Orange Bowl semifinal with a shot at the national title matchup on the line. Here’s the latest prediction for the game from an expert analytical model that projects scores and picks winners.

For the first time in 17 years, Notre Dame and Penn State are set to face off on a football field. This time, there's a lot on the line, as the 7-seed Fighting Irish will play the 6-seed Nittany Lions in the Orange Bowl,

Either the Irish or the Nittany Lions will look to book a trip to the Jan. 20 CFP national championship game at Mercedes-Benz Stadium in Atlanta.