Simply put, orthogonal validation uses additional methods that provide very different selectivity to the primary method to confirm or refute a finding. All methods are independent approaches that can ...

Combining orthogonal loss-of-function (LOF) methods in parallel (orthogonal validation) can help reduce the possibility of spurious results (false negative or positive results). In this manner, ...

The computer revolution has had surprisingly little impact on the philosophy, theory, teaching and practical use of experimental design. This absence of effect can be seen most clearly in the ...