Molecular Pathways and Mechanisms of BRAF in Cancer Therapy
With the emergence of a deeper understanding of how BRAF mutations signal through the RAS/mitogen activated protein kinase (MAPK) pathway, newer RAF inhibitors are being developed that may be …
BRAF (gene) - Wikipedia
Overview of signal transduction pathways involved in apoptosis. The role of Raf proteins like B-Raf is indicated in the center. B-Raf is a member of the Raf kinase family of growth signal transduction …
BRAF Mutation and Cancer - Johns Hopkins Medicine
BRAF gene mutations can cause normal cells to become cancerous. Learn about the mutation, the types of cancer it can cause and the treatments available.
BRAF gene: MedlinePlus Genetics
The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. This protein is part of a signaling pathway known as the …
The BRAF-MAPK Pathway’s Role in Cell Growth and Cancer
Jun 11, 2025 · The BRAF gene provides instructions for a protein within a cellular communication network known as the Mitogen-Activated Protein Kinase (MAPK) pathway. This chain of proteins …
Exploring the pathway: clinical utility and open challenges of ...
Mar 1, 2025 · The BRAF proto-oncogene plays a key role in oncogenesis, promoting growth and survival through various genetic alterations. Most mutations involve the substitution of valine at amino acid …
BRAF gene: From human cancers to developmental syndromes
The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies).
BRAF — a tumour-agnostic drug target with lineage-specific ... - Nature
Jan 26, 2024 · In this Review, we describe the biochemical basis for oncogenic BRAF-induced activation of MAPK signalling and pan-cancer and lineage-specific mechanisms of intrinsic, adaptive and …
BRAF Gene - GeneCards | BRAF Protein | BRAF Antibody
Jan 14, 2026 · BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with BRAF include Lung Cancer and Cardiofaciocutaneous Syndrome 1. …
Molecular Targeting of the BRAF Proto-Oncogene/Mitogen-Activated …
Jan 3, 2024 · Here, this comprehensive review will cover the developments of BRAF and MEK inhibitors from melanomas to tumor-agnostic indications, novel drugs, challenges, future directions, and the …