Proposed model of hepatitis E virus replication. Adapted from Expert ...
Hepatitis E virus (HEV) is increasingly recognized as the leading cause of acute hepatitis. Although HEV infections are mostly self-limiting, a chronic course can develop especially in...
Hepatitis E: Molecular Virology and Pathogenesis - PMC
The recent developments in understanding the structure, entry, egress, host interactions and functional characterization of the HEV proteins helped in further providing a better insight in …
Stem cell-derived hepatocytes: A novel model for hepatitis E virus ...
We studied whether pluripotent stem cell (PSC)-derived hepatocytes, mesodermal and/or neuroprogenitor cells support HEV replication. Human PSC were differentiated towards …
Proliferative Cell Targeting and Epithelial Cell Turnover Fuels ...
Overall, we established a robust HEV-HIE model that yields high titers of infectious nonenveloped virions. Proliferative cells and the fast intestinal epithelial cell turnover are important features …
New Models to Study Hepatitis E Virus Replication and …
Finally, the novel cell culture model and the new insights generated in the biology of HEV replication, with infectious HEV particles or “needles” hiding in the stack of ORF2 g and ORF2 …
Expanding the Hepatitis E Virus Toolbox: Selectable Replicons …
Here, we provide an overview on currently available systems, with an emphasis on selectable replicons and recombinant reporter genomes. Furthermore, we discuss the challenges in …
A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture.
Hepatitis E Virus Genome Structure and Replication Strategy
All recently proposed reference strains for hepatitis E virus (HEV) (Smith et al. 2014, 2016) were aligned and placed into a circular phylogenetic tree using Geneious software v10.2.2 by …
In vivo models for studying Hepatitis E virus infection; Updates …
Dec 1, 2019 · In this review, we give updates on the animal models used for studying HEV infection, focusing on the applicability of each model in studying different HEV infections, cross …
Stem Cell–Derived Culture Models of Hepatitis E Virus Infection
Stem cell culture models of hepatitis E virus (HEV) infection. Cells collected from identified HEV-positive individuals can be reprogrammed to generate induced pluripotent stem cells (iPSCs).