Oncogenic driver mutations in non-small cell lung cancer ...
In recent years, more of these so-called oncogenic drivers have been identified, and a better understanding of their biology has allowed the development new targeted agents. This review aims …
Gene Mutations in Non-Small-Cell Lung Cancer - WebMD
If you have non-small-cell lung cancer (NSCLC), your disease began with changes to your genes. These changes, called "mutations," cause your lung cells to grow out of control.
Targeting mutations that drive lung cancer - Nature
A plethora of driver genes for NSCLC has been identified, paving the path to the targeted therapy revolution, where the effects of cancer-causing mutations are countered with drugs.
Lung Cancer Mutations: TP53, KRAS, EGFR, ALK, and More
5 days ago · Gene mutations linked to non-small cell lung cancer (NSCLC) can be inherited (germline) or acquired (somatic). These changes can stop DNA repair and drive uncontrolled cell growth. …
Revisiting variation in the somatic mutation landscape of non ...
Apr 10, 2025 · Non-small cell lung cancer (NSCLC) is driven by a diverse array of somatic mutations. The vast majority of literature on NSCLC is based on targeted assays or small sample sizes, limiting …
Topography of mutational signatures in non-small cell lung ...
Jun 22, 2024 · For non-small cell lung cancer, several mutational signatures have been identified that correlate with exposures such as tobacco smoking and radon and can also reflect endogenous …
A genome-wide genetic screen reveals the P2Y2-integrin axis ...
5 days ago · Activating mutations in the epidermal growth factor receptor (EGFR) gene drive non–small cell lung cancer (NSCLC). Oncogenic EGFR mutants are ligand-independent and more stable, but …