“ Beetlejuice Beetlejuice,” the sequel to Tim Burton’s 1988 horror comedy about a pesky poltergeist, scored a huge $110 million from 4,575 theaters in its opening weekend. Those ticket sales rank as the second-biggest September debut of all time, ahead of 2019’s “It: Chapter 2” ($91 million debut) and behind only 2017’s “It” ($123 million debut).

The horror comedy is ready to take over the box office, after a slow end to August, with an estimated $100 million to $110 million opening this weekend. That’s a scary good debut, since the film carries a production budget of $100 million.

The pic, playing in 4,575 theaters domestically, fell just 54 percent for a 10-day domestic total of $188 million. Overseas, the sequel took in another $28.7 million from 76 markets for a lukewarm foreign tally of $76.3 million and $264.3 million globally.

After a roaring $120 million start at the global box office, Beetlejuice 2 continued to hold strong, raking in $25 million domestically in its third weekend for a running statewide total of $225 million. With a $76.5 million overseas gross, Beetlejuice Beetlejuice has earned over $301 million worldwide.